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lüll Borna disease virus: a unique pathogen and its interaction with intracellular signalling pathways Planz O; Pleschka S; Wolff TCell Microbiol 2009[Jun]; 11 (6): 872-9Borna disease virus (BDV) is a neurotropic RNA virus that establishes non-cytolytic persistent infection in the central nervous system of warm-blooded animals. Depending on the host species and the route of infection, BDV persistence can modulate neuronal plasticity and animal behaviour and/or may provoke a T cell-mediated immunopathological reaction with high mortality. Therefore, BDV functions as a model pathogen to study persistent virus infection in the central nervous system. Here, we review recent evidence showing that BDV interferes with a spectrum of intracellular signalling pathways, which may be involved in viral spread, maintenance of persistence and modulation of neurotransmitter pathways.|*Host-Pathogen Interactions[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Borna disease virus/*immunology/*pathogenicity[MESH]|Central Nervous System/immunology/pathology/*virology[MESH] |