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lüll Carbon monoxide diffusion capacity: how low can you go for hematopoietic cell transplantation eligibility?Chien JW; Sullivan KMBiol Blood Marrow Transplant 2009[Apr]; 15 (4): 447-53Current guidelines suggest that patients with a pretransplantation diffusion capacity of the lung for carbon monoxide (DLCO) < or = 60% are not ideal candidates for hematopoietic cell transplantation (HCT); however, recent studies suggest this criterion may exclude patients who will benefit from the procedure. We conducted a study of all adult patients who underwent autologous or allogeneic HCT between 1990 and 2005, and had a DLCO < 60%, of predicted normal, to examine whether there is a lower limit for the DLCO threshold in the context of respiratory failure and nonrelapse mortality risk (NRM), and whether a comprehensive risk scoring system, such as the Pretransplant Assessment of Mortality (PAM) risk score, can more effectively risk stratify these patients with a very low pretransplantation DLCO. We found that among patients with a DLCO < or = 60% the risk of respiratory failure or NRM was not significantly different; however, the PAM score effectively risk-stratified these patients for NRM risk. There was a stepwise relationship between PAM score category and NRM risk; the highest PAM score category was associated with a 4.38-fold increase in risk (P < .001). These findings suggest that the pretransplantation DLCO should not be considered the sole eligibility criteria for allogeneic HCT.|*Carbon Monoxide[MESH]|*Hematopoietic Stem Cell Transplantation[MESH]|Adult[MESH]|Diffusion[MESH]|Female[MESH]|Guidelines as Topic[MESH]|Hematologic Neoplasms/*mortality/physiopathology/*therapy[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Respiratory Function Tests[MESH]|Respiratory Insufficiency/metabolism/*mortality/physiopathology[MESH]|Retrospective Studies[MESH]|Risk Factors[MESH]|Transplantation, Autologous[MESH]|Transplantation, Homologous[MESH] |