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lüll Cancer gene discovery in mouse and man Mattison J; van der Weyden L; Hubbard T; Adams DJBiochim Biophys Acta 2009[Dec]; 1796 (2): 140-61The elucidation of the human and mouse genome sequence and developments in high-throughput genome analysis, and in computational tools, have made it possible to profile entire cancer genomes. In parallel with these advances mouse models of cancer have evolved into a powerful tool for cancer gene discovery. Here we discuss the approaches that may be used for cancer gene identification in both human and mouse and discuss how a cross-species 'oncogenomics' approach to cancer gene discovery represents a powerful strategy for finding genes that drive tumourigenesis.|*Genes, Neoplasm[MESH]|Animals[MESH]|Comparative Genomic Hybridization[MESH]|DNA Transposable Elements[MESH]|Epigenesis, Genetic[MESH]|Gene Dosage[MESH]|Genetic Engineering[MESH]|Humans[MESH]|Mice[MESH]|Mutagenesis, Insertional[MESH]|Neoplasms/*genetics[MESH] |