Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll How B cells shape the immune response against Mycobacterium tuberculosis Maglione PJ; Chan JEur J Immunol 2009[Mar]; 39 (3): 676-86Extensive work illustrating the importance of cellular immune mechanisms for protection against Mycobacterium tuberculosis has largely relegated B-cell biology to an afterthought within the tuberculosis (TB) field. However, recent studies have illustrated that B lymphocytes, through a variety of interactions with the cellular immune response, play previously underappreciated roles in shaping host defense against non-viral intracellular pathogens, including M. tuberculosis. Work in our laboratory has recently shown that, by considering these lymphocytes more broadly within their variety of interactions with cellular immunity, B cells have a significant impact on the outcome of airborne challenge with M. tuberculosis as well as the resultant inflammatory response. In this review, we advocate for a revised view of TB immunology in which roles of cellular and humoral immunity are not mutually exclusive. In the context of our current understanding of host defense against non-viral intracellular infections, we review recent data supporting a more significant role of B cells during M. tuberculosis infection than previously thought.|Animals[MESH]|Antibody Formation[MESH]|B-Lymphocytes/*immunology/metabolism[MESH]|Cell Communication/immunology[MESH]|Cytokines/immunology/metabolism[MESH]|Humans[MESH]|Immunity, Cellular[MESH]|Immunologic Memory/immunology[MESH]|Lymphocyte Activation/immunology[MESH]|Mycobacterium tuberculosis/*immunology[MESH]|Receptors, IgG/*immunology/metabolism[MESH]|T-Lymphocytes/*immunology/metabolism[MESH]|Tuberculosis/*immunology/microbiology[MESH] |