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lüll Discovery of alpha-Klotho unveiled new insights into calcium and phosphate homeostasis Nabeshima YProc Jpn Acad Ser B Phys Biol Sci 2009[]; 85 (3): 125-41alpha-Klotho was first identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. alpha-Klotho has been shown to participate in the regulation of parathyroid hormone secretion and trans-epithelial transport of Ca(2+) in the choroid plexus and kidney. alpha-Klotho, acting as a cofactor for FGF23, is also a major regulator of vitamin D biosynthesis and phosphate reabsorption in the kidney. These suggest that alpha-Klotho is a key player that integrates a multi-step regulatory system of calcium and phosphate homeostasis. Collectively, the molecular function of alpha-Klotho reveals a new paradigm that may change current concepts in mineral homeostasis and give rise to new insights in this field.|*Homeostasis[MESH]|Animals[MESH]|Calcium/*metabolism[MESH]|Fibroblast Growth Factor-23[MESH]|Glucuronidase/genetics/*metabolism[MESH]|Humans[MESH]|Klotho Proteins[MESH]|Parathyroid Hormone/metabolism[MESH]|Phosphates/*metabolism[MESH]|Sodium-Potassium-Exchanging ATPase/metabolism[MESH] |