Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
AMPK: Lessons from transgenic and knockout animals Viollet B; Athea Y; Mounier R; Guigas B; Zarrinpashneh E; Horman S; Lantier L; Hebrard S; Devin-Leclerc J; Beauloye C; Foretz M; Andreelli F; Ventura-Clapier R; Bertrand LFront Biosci (Landmark Ed) 2009[Jan]; 14 (1): 19-44AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine protein kinase, has been proposed to function as a fuel gauge to monitor cellular energy status in response to nutritional environmental variations. AMPK system is a regulator of energy balance that, once activated by low energy status, switches on ATP-producing catabolic pathways (such as fatty acid oxidation and glycolysis), and switches off ATP-consuming anabolic pathways (such as lipogenesis), both by short-term effect on phosphorylation of regulatory proteins and by long-term effect on gene expression. Numerous observations obtained with pharmacological activators and agents that deplete intracellular ATP have been supportive of AMPK playing a role in the control of energy metabolism but none of these studies have provided conclusive evidence. Relatively recent developments in our understanding of precisely how AMPK complexes might operate to control energy metabolism is due in part to the development of transgenic and knockout mouse models. Although there are inevitable caveats with genetic models, some important findings have emerged. In the present review, we discuss recent findings obtained from animal models with inhibition or activation of AMPK signaling pathway.|AMP-Activated Protein Kinases/chemistry/*metabolism[MESH]|Adipose Tissue/enzymology[MESH]|Animals[MESH]|Animals, Genetically Modified[MESH]|Blood Vessels/enzymology/physiology[MESH]|Energy Metabolism[MESH]|Gene Knockout Techniques[MESH]|Humans[MESH]|Hypoglycemic Agents/pharmacology[MESH]|Hypothalamus/enzymology[MESH]|Insulin Resistance[MESH]|Liver/enzymology[MESH]|Models, Animal[MESH]|Muscle, Skeletal/enzymology[MESH]|Myocardium/enzymology[MESH]|Protein Conformation[MESH] |
