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C-peptide in the natural history of type 1 diabetes Palmer JPDiabetes Metab Res Rev 2009[May]; 25 (4): 325-8Type 1 diabetes is diagnosed when the patient's endogenous insulin secretion decreases to a level which results in hyperglycemia. After diagnosis, insulin secretion continues to decline. As a reference for clinical trials trying to preserve endogenous beta-cell function in patients with recently diagnosed type 1 diabetes, in this short review I attempt to summarize the natural history of endogenous beta-cell function after the diagnosis of type 1 diabetes.|C-Peptide/*metabolism[MESH]|Diabetes Mellitus, Type 1/immunology/metabolism/*physiopathology[MESH]|Humans[MESH]|Insulin Secretion[MESH]|Insulin-Secreting Cells/*metabolism[MESH]|Insulin/metabolism[MESH] |
