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lüll X chromosome inactivation sparked by non-coding RNAs Leeb M; Steffen PA; Wutz ARNA Biol 2009[Apr]; 6 (2): 94-9Non-coding RNAs regulate dosage compensation in mammals by controlling transcriptional silencing of one of the two X chromosomes in females. The two major transcripts involved in this process are Xist and its antisense counterpart Tsix. Expression of Xist and Tsix from the X inactivation center is mutually exclusive. Xist expression triggers chromosome wide silencing of the X chromosome from which it is transcribed. Tsix is a repressor of Xist and is specifically expressed from the other X chromosome, maintaining its activity. Here, we review non-coding RNAs that have been implicated in X chromosome inactivation. Focusing on the best studied transcripts Xist and Tsix we portray a current perspective on chromosome wide gene regulation by non-coding RNAs.|*X Chromosome Inactivation[MESH]|Animals[MESH]|Female[MESH]|Gene Dosage[MESH]|Gene Expression Regulation[MESH]|Gene Silencing[MESH]|Humans[MESH]|Mice[MESH]|RNA, Long Noncoding[MESH]|RNA, Untranslated/genetics/*physiology[MESH] |