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mRNA localization: gene expression in the spatial dimension Martin KC; Ephrussi ACell 2009[Feb]; 136 (4): 719-30The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control. Recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell.|*RNA Transport[MESH]|Animals[MESH]|Cytoplasm/metabolism[MESH]|Humans[MESH]|RNA, Messenger/*metabolism[MESH]|RNA-Binding Proteins/metabolism[MESH]|Regulatory Sequences, Ribonucleic Acid[MESH] |
