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Progressive supranuclear palsy: a review of co-existing neurodegeneration Keith-Rokosh J; Ang LCCan J Neurol Sci 2008[Nov]; 35 (5): 602-8OBJECTIVES: The neuropathological findings of 32 progressive supranuclear palsy (PSP) cases over a period of 17 years were reviewed. RESULTS: Of the 26 cases with adequate clinical data, 20 patients either presented with cognitive dysfunction or developed a cognitive impairment subsequently during the course of the disease. Co-existing changes of argyrophilic grains and corticobasal degeneration (CBD) were found in 28% and 32% of the cases respectively. Alzheimer-related pathology was found in 69% of cases but only 18.75% of cases fulfilled the consortium to establish a registry for Alzheimer's disease (CERAD) criteria for either definite or probable Alzheimer's disease. Lewy bodies were noted in four cases (12.5%), all in the subcortical regions. Only seven cases of PSP showed no pathological evidence of other co-existing neurodegenerative diseases. The severity of the cerebrovascular pathology in this cohort was insufficient to explain any clinical symptomatology. CONCLUSIONS: As in previous studies, this study has demonstrated the frequent co-existence of pathological changes usually noted in other neurodegenerative diseases in PSP. Whether these co-existing pathological changes contribute to the cognitive impairment in PSP remains uncertain.|Aged[MESH]|Aged, 80 and over[MESH]|Alzheimer Disease/complications/pathology/physiopathology[MESH]|Axons/pathology[MESH]|Brain/*pathology/physiopathology[MESH]|Cerebrovascular Disorders/complications/pathology/physiopathology[MESH]|Cohort Studies[MESH]|Comorbidity[MESH]|Female[MESH]|Humans[MESH]|Lewy Bodies/pathology[MESH]|Male[MESH]|Middle Aged[MESH]|Neurodegenerative Diseases/*complications/*pathology/physiopathology[MESH]|Neurons/pathology[MESH]|Ontario[MESH]|Retrospective Studies[MESH]|Silver Staining[MESH]|Supranuclear Palsy, Progressive/*complications/*pathology/physiopathology[MESH] |
