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IL-17F: regulation, signaling and function in inflammation Chang SH; Dong CCytokine 2009[Apr]; 46 (1): 7-11The IL-17 cytokine family is composed of six members. IL-17F, discovered in 2001, recently has drawn increasing attention due to its greatest similarity to IL-17, a widely recognized inflammatory cytokine. The genes encoding IL-17 and IL-17F are localized in the same chromosomal region and are co-expressed by CD4+ and gammadelta T cells. IL-17F can be secreted as homodimers or heterodimers with IL-17. Similar to IL-17, IL-17F utilizes IL-17RA and IL-17RC as its receptor and employs Act1 and TRAF6 as its signal transducers to induce the expression of pro-inflammatory cytokines and chemokines in many different cell types. However, mice lacking either IL-17 or IL-17F exhibit distinct defects in experimental models of asthma and colitis. These results have laid the basis to understand the role of IL-17F in the pathogenesis of human diseases.|*Gene Expression Regulation[MESH]|Adaptor Proteins, Signal Transducing[MESH]|Animals[MESH]|Autoimmune Diseases/metabolism[MESH]|CD4-Positive T-Lymphocytes/metabolism[MESH]|Cytokines/metabolism[MESH]|Dimerization[MESH]|Humans[MESH]|Inflammation/*metabolism[MESH]|Interleukin-17/genetics/metabolism/*physiology[MESH]|Intestinal Mucosa/metabolism[MESH]|Models, Biological[MESH]|Neurons/metabolism[MESH]|Signal Transduction[MESH]|TNF Receptor-Associated Factor 6/metabolism[MESH]|Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/metabolism[MESH] |
