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Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility Kim TY; Vigil D; Der CJ; Juliano RLCancer Metastasis Rev 2009[Jun]; 28 (1-2): 77-83DLC-1 was originally identified as a potential tumor suppressor. One of the key biochemical functions of DLC-1 is to serve as a GTPase activating protein (GAP) for members of the Rho family of GTPases, particularly Rho A-C and Cdc 42. Since these GTPases are critically involved in regulation of the cytoskeleton and cell migration, it seems clear that DLC-1 will also influence these processes. In this review we examine basic aspects of the actin cyoskeleton and how it relates to cell motility. We then delineate the characteristics of DLC-1 and other members of its family, and describe how they may have multiple effects on the regulation of cell polarity, actin organization, and cell migration.|Animals[MESH]|Cell Movement[MESH]|Cytoskeleton/*metabolism[MESH]|GTPase-Activating Proteins/*metabolism[MESH]|Humans[MESH]|Mice[MESH]|Models, Biological[MESH]|Neoplasm Invasiveness[MESH]|Neoplasm Metastasis[MESH]|Signal Transduction[MESH]|Tumor Suppressor Proteins/metabolism/*physiology[MESH]|rho GTP-Binding Proteins/metabolism[MESH]|rhoA GTP-Binding Protein/metabolism[MESH]|rhoB GTP-Binding Protein/metabolism[MESH]|rhoC GTP-Binding Protein[MESH] |
