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lüll Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression Peter MECell Cycle 2009[Mar]; 8 (6): 843-52Micro (mi)RNAs are emerging as important regulators of cellular differentiation, their importance underscored by the fact that they are often dysregulated during carcinogenesis. Two evolutionary conserved families, let-7 and miR-200, regulate key differentiation processes during development. Loss of let-7 in cancer results in reverse embryogenesis and dedifferentiation, and miR-200 has been identified as a powerful regulator of epithelial-to-mesenchymal transition (EMT). Recent findings have connected let-7 with stem cell maintenance and point at a connection between EMT and stem cell formation. A part of tumor progression can be viewed as a continuum of progressive dedifferentiation (EMT) with a cell at the endpoint that has stem cell-like properties. I propose that steps of this process are driven by specific changes in the expression of let-7 and miR-200 family members.|Animals[MESH]|Cell Differentiation/genetics[MESH]|Humans[MESH]|Mice[MESH]|MicroRNAs/genetics/*metabolism[MESH]|Neoplasms/metabolism/*pathology[MESH]|Neoplastic Stem Cells/metabolism/*pathology[MESH]|Pluripotent Stem Cells/metabolism/*pathology[MESH]|Signal Transduction/physiology[MESH]|Transcription Factors/metabolism[MESH] |