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lüll Chromatin dynamics coupled to DNA repair Huertas D; Sendra R; Munoz PEpigenetics 2009[Jan]; 4 (1): 31-42In order to protect and preserve the integrity of the genome, eukaryotic cells have developed accurate DNA repair pathways involving a coordinated network of DNA repair and epigenetic factors. The DNA damage response has to proceed in the context of chromatin, a packaged and compact structure that is flexible enough to regulate the accession of the DNA repair machinery to DNA-damaged sites. Chromatin modifications and ATP-remodeling activities are both necessary to ensure efficient DNA repair. Here we review the current progress of research into the importance of chromatin modifications and the ATP-remodeling complex to the DNA damage response, with respect to the sensing and signaling of DNA lesions, DNA repair and the processes that restore chromatin structure.|*DNA Repair[MESH]|Adenosine Triphosphate/chemistry[MESH]|Animals[MESH]|Chromatin Assembly and Disassembly[MESH]|Chromatin/*chemistry/genetics/metabolism[MESH]|Chromosomes/ultrastructure[MESH]|DNA Breaks, Double-Stranded[MESH]|DNA Damage[MESH]|Drosophila melanogaster/metabolism[MESH]|Histones/metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Protein Structure, Tertiary[MESH]|Saccharomyces cerevisiae/metabolism[MESH] |