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lüll D-amino acid oxidase: physiological role and applications Khoronenkova SV; Tishkov VIBiochemistry (Mosc) 2008[Dec]; 73 (13): 1511-8D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormone secretion, and other processes by D-amino acids as well as development of different diseases under changed DAAO activity are presented. The mechanism of regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects. Use of DAAO for diagnostic and therapeutic purposes is also considered.|Amino Acids/metabolism[MESH]|Animals[MESH]|D-Amino-Acid Oxidase/biosynthesis/chemistry/*metabolism[MESH]|Eukaryotic Cells/metabolism[MESH]|Humans[MESH]|Saccharomycetales/enzymology[MESH] |