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lüll Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing Clark RA; Pavlis MJ Invest Dermatol 2009[Mar]; 129 (3): 529-31Either heredity mutations or adverse microenvironment conditions may result in dysregulation of the mammalian target of the rapamycin (mTOR) pathway. The former lead to clinical syndromes such as tuberous sclerosis, Peutz-Jeghers syndrome, and Cowden's disease, which are characterized by hamartomatous growth or cancer. The latter can be associated with poor wound healing as described by Goren et al. (2009, this issue).|*Gene Expression Regulation, Neoplastic[MESH]|*Mutation[MESH]|*Wound Healing[MESH]|Animals[MESH]|Hamartoma Syndrome, Multiple/genetics[MESH]|Hamartoma/genetics[MESH]|Humans[MESH]|Mice[MESH]|Neovascularization, Pathologic[MESH]|Peutz-Jeghers Syndrome/metabolism[MESH]|Phosphatidylinositol 3-Kinases/metabolism[MESH]|Protein Kinases/*biosynthesis/*genetics[MESH]|TOR Serine-Threonine Kinases[MESH]|Tuberous Sclerosis Complex 1 Protein[MESH]|Tuberous Sclerosis Complex 2 Protein[MESH]|Tuberous Sclerosis/metabolism[MESH]|Tumor Suppressor Proteins/metabolism[MESH] |