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 Atypical E2Fs: new players in the E2F transcription factor family Lammens T; Li J; Leone G; De Veylder LTrends Cell Biol  2009[Mar]; 19 (3): 111-8As major regulators of the cell cycle, apoptosis and differentiation, E2F  transcription factors have been studied extensively in a broad range of  organisms. The recent identification of atypical E2F family members further  expands our structural, functional and molecular view of the cellular E2F  activity. Unlike other family members, atypical E2Fs have a duplicated  DNA-binding domain and control gene expression without heterodimerization with  dimerization partner proteins. Recently, knockout strategies in plants and  mammals have pinpointed that atypical E2Fs have a crucial role in plant cell size  control, endocycle regulation, proliferation and apoptotic response upon DNA  stress. Their position at the crossroads of proliferation and DNA stress response  marks these novel E2F proteins as interesting study objects in the field of tumor  biology.|Animals[MESH]|Arabidopsis Proteins/biosynthesis/chemistry/genetics/physiology[MESH]|Arabidopsis/chemistry/genetics/physiology[MESH]|E2F Transcription Factors/*chemistry/deficiency/genetics/*physiology[MESH]|E2F7 Transcription Factor/chemistry/deficiency/physiology[MESH]|Humans[MESH]|Multigene Family/genetics/*physiology[MESH]|Repressor Proteins/chemistry/genetics/physiology[MESH]
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