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Physiological role of plasmacytoid dendritic cells and their potential use in cancer immunity Schettini J; Mukherjee PClin Dev Immunol 2008[]; 2008 (ä): 106321Dendritic cells (DCs) play a pivotal role in the control of innate and adaptive immune responses. They are a heterogeneous cell population, where plasmacytoid dendritic cells (pDCs) are a unique subset capable of secreting high levels of type I IFNs. It has been demonstrated that pDCs can coordinate events during the course of viral infection, atopy, autoimmune diseases, and cancer. Therefore, pDC, as a main source of type I IFN, is an attractive target for therapeutic manipulations of the immune system to elicit a powerful immune response against tumor antigens in combination with other therapies. The therapeutic vaccination with antigen-pulsed DCs has shown a limited efficacy to generate an effective long-lasting immune response against tumor cells. A rational manipulation and design of vaccines which could include DC subsets outside "Langerhans cell paradigm" might allow us to improve the therapeutic approaches for cancer patients.|Animals[MESH]|Antigen Presentation/immunology[MESH]|Antigens, Neoplasm/*immunology/metabolism[MESH]|Cancer Vaccines/*immunology/therapeutic use[MESH]|Cell Differentiation/immunology[MESH]|Cell Movement[MESH]|Dendritic Cells/*immunology/metabolism/pathology[MESH]|Gene Expression Regulation/immunology[MESH]|Humans[MESH]|Immunity, Cellular[MESH]|Interferon Type I/immunology/*metabolism[MESH]|Neoplasms/*immunology/pathology/*therapy[MESH] |
