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lüll The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis Korpal M; Kang YRNA Biol 2008[Jul]; 5 (3): 115-9MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.|Animals[MESH]|Epithelium/*pathology[MESH]|Humans[MESH]|Mesoderm/*pathology[MESH]|MicroRNAs/*metabolism[MESH]|Neoplasm Metastasis/*genetics[MESH]|Neoplasms/genetics/pathology[MESH]|Transcription Factors/metabolism[MESH] |