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  • The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis
  • Korpal M; Kang Y
  • RNA Biol 2008[Jul]; 5 (3): 115-9
  • MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.
  • |Animals[MESH]
  • |Epithelium/*pathology[MESH]
  • |Humans[MESH]
  • |Mesoderm/*pathology[MESH]
  • |MicroRNAs/*metabolism[MESH]
  • |Neoplasm Metastasis/*genetics[MESH]
  • |Neoplasms/genetics/pathology[MESH]
  • |Transcription Factors/metabolism[MESH]





  • *{{pmid19182522}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=19182522 The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis ]</b> RNA Biol 2008; 5(3) ; 115-9 Korpal M; Kang Y

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    RNA Biol

    115 3.5 2008