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The role of L-methylfolate in depressive disorders Farah ACNS Spectr 2009[Jan]; 14 (1 Suppl 2): 2-7Major depressive disorder (MDD) is a debilitating and often recurrent illness. An initial antidepressant trial is effective at achieving remission for approximately 30% of patients when prescribed as monotherapy, with the majority of patients returning as partial or non-responders. Switching antidepressants or adding augmentation agents are standard therapeutic options used to achieve and maintain remission. Suboptimal serum and red blood cell folate levels have been associated with a poorer response to antidepressant therapy, a greater severity of symptoms, later onset of clinical improvement, and overall treatment resistance. This Expert Review Supplement reviews the evidence for L-methylfolate as an augmentation agent in depression and discusses its clinical use elaborated by three clinical presentations.|Adult[MESH]|Antidepressive Agents/adverse effects/*therapeutic use[MESH]|Depressive Disorder, Major/blood/*drug therapy[MESH]|Drug Therapy, Combination[MESH]|Female[MESH]|Folic Acid/blood/*therapeutic use[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Vitamin B Complex/therapeutic use[MESH] |
