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lüll Vascular endothelial growth factor Ferrara NArterioscler Thromb Vasc Biol 2009[Jun]; 29 (6): 789-91Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.|*Neovascularization, Physiologic/drug effects[MESH]|*Signal Transduction/drug effects[MESH]|Angiogenesis Inhibitors/pharmacology[MESH]|Animals[MESH]|Endothelial Cells/metabolism[MESH]|History, 20th Century[MESH]|History, 21st Century[MESH]|Humans[MESH]|Neoplasms/blood supply/drug therapy[MESH]|Receptors, Vascular Endothelial Growth Factor/metabolism[MESH]|Vascular Endothelial Growth Factor A/antagonists & inhibitors/history/*metabolism[MESH] |