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lüll Imaging surrogates of tumor response to therapy: anatomic and functional biomarkers Zhao B; Schwartz LH; Larson SMJ Nucl Med 2009[Feb]; 50 (2): 239-49This article addresses the current status of quantitative imaging as a surrogate biomarker for the assessment of tumor response to therapy with non-small cell lung cancer as an example. In addition, the article discusses the limitations of conventional response criteria in the new era of molecular-targeted agents for cancer treatment; the increasing need for more accurate and early response-assessment methods, particularly for volumetric CT; new tumor-specific radiotracers and molecular imaging technologies; and the future applications of molecular imaging with PET for studying various features of cancer metabolism, endocrine status, hypoxia, and oncofetal and differentiation antigens.|Animals[MESH]|Biomarkers, Tumor/metabolism[MESH]|Carcinoma, Non-Small-Cell Lung/diagnostic imaging/therapy[MESH]|Female[MESH]|Fluorine Radioisotopes[MESH]|Fluorodeoxyglucose F18[MESH]|Humans[MESH]|Lung Neoplasms/diagnostic imaging/therapy[MESH]|Male[MESH]|Neoplasms/*diagnostic imaging/therapy[MESH]|Positron-Emission Tomography[MESH]|Radiopharmaceuticals[MESH]|Tomography, X-Ray Computed[MESH] |