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lüll Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation Maynard CL; Weaver CTImmunol Rev 2008[Dec]; 226 (ä): 219-33Recent progress in our understanding of mechanisms by which the immunosuppressive cytokine interleukin-10 (IL-10) participates in an ever-increasing diversity of T-cell lineages to maintain immune homeostasis has broadened the framework for defining regulatory and effector T cells and has blurred the lines between them. In this review, we highlight established and emerging roles for IL-10 produced by distinct CD4(+) T-cell lineages that underlie its non-redundant role in curbing immune responses to the intestinal microbiota at steady state and its role to limit T-cell-driven inflammation in responses to pathogens.|Animals[MESH]|Cytokines/*immunology/metabolism[MESH]|Forkhead Transcription Factors/*immunology/metabolism[MESH]|Humans[MESH]|Inflammation/*immunology/metabolism[MESH]|Interleukin-10/*immunology/metabolism[MESH]|Intestines/immunology/microbiology[MESH]|T-Lymphocyte Subsets/*immunology/metabolism[MESH]|T-Lymphocytes, Regulatory/*immunology/metabolism[MESH] |