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Regulation and pro-inflammatory function of interleukin-17 family cytokines Dong CImmunol Rev 2008[Dec]; 226 (ä): 80-6The interleukin-17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4(+) helper T cells and play critical function in inflammation and autoimmunity. IL-17E, also called IL-25, has been associated with allergic responses. Here, I summarize recent work by my laboratory as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.|Animals[MESH]|Chemokines/immunology/metabolism[MESH]|Humans[MESH]|Hypersensitivity/immunology/metabolism[MESH]|Inflammation/*immunology/metabolism[MESH]|Interleukin-17/*immunology/metabolism[MESH]|Matrix Metalloproteinases/immunology/metabolism[MESH]|Signal Transduction/immunology[MESH]|T-Lymphocytes, Helper-Inducer/*immunology/metabolism[MESH] |
