Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Myelin-associated glycoprotein and its axonal receptors Schnaar RL; Lopez PHJ Neurosci Res 2009[Nov]; 87 (15): 3267-76Myelin-associated glycoprotein (MAG) is expressed on the innermost myelin membrane wrap, directly apposed to the axon surface. Although it is not required for myelination, MAG enhances long-term axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon cytoskeleton. In addition to its role in axon-myelin stabilization, MAG inhibits axon regeneration after injury; MAG and a discrete set of other molecules on residual myelin membranes at injury sites actively signal axons to halt elongation. Both the stabilizing and the axon outgrowth inhibitory effects of MAG are mediated by complementary MAG receptors on the axon surface. Two MAG receptor families have been described, sialoglycans (specifically gangliosides GD1a and GT1b) and Nogo receptors (NgRs). Controversies remain about which receptor(s) mediates which of MAG's biological effects. Here we review the findings and challenges in associating MAG's biological effects with specific receptors.|Animals[MESH]|Gangliosides/metabolism[MESH]|Growth Cones/*metabolism/ultrastructure[MESH]|Growth Inhibitors/*metabolism[MESH]|Humans[MESH]|Myelin Proteins/metabolism[MESH]|Myelin Sheath/*metabolism/ultrastructure[MESH]|Myelin-Associated Glycoprotein/*metabolism/ultrastructure[MESH]|Nerve Fibers, Myelinated/*metabolism/ultrastructure[MESH]|Nogo Proteins[MESH]|Receptors, Cell Surface/*metabolism[MESH]|Signal Transduction/physiology[MESH] |
