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lüll Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system Debruyne JPJ Genet 2008[Dec]; 87 (5): 437-46A functional mouse CLOCK protein has long been thought to be essential for mammalian circadian clockwork function, based mainly on studies of mice bearing a dominant negative, antimorphic mutation in the Clock gene. However, new discoveries using recently developed Clock-null mutant mice have shaken up this view. In this review, I discuss how this recent work impacts and alters the previous view of the role of CLOCK in the mouse circadian clockwork.|Animals[MESH]|Basic Helix-Loop-Helix Transcription Factors/genetics/physiology[MESH]|Biological Clocks/*genetics[MESH]|CLOCK Proteins[MESH]|Circadian Rhythm/*genetics[MESH]|Gene Expression Regulation/physiology[MESH]|Humans[MESH]|Mice, Knockout[MESH]|Mice/*genetics/physiology[MESH]|Models, Biological[MESH]|Nerve Tissue Proteins/genetics/physiology[MESH]|Trans-Activators/*genetics/physiology[MESH] |