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lüll mTOR: dissecting regulation and mechanism of action to understand human disease Goberdhan DC; Boyd CABiochem Soc Trans 2009[Feb]; 37 (Pt 1): 213-6mTOR (mammalian target of rapamycin) is a highly conserved serine/threonine protein kinase that has roles in cell metabolism, cell growth and cell survival. Although it has been known for some years that mTOR acts as a hub for inputs from growth factors (in particular insulin and insulin-like growth factors), nutrients and cellular stresses, some of the mechanisms involved are still poorly understood. Recent work has implicated mTOR in a variety of important human pathologies, including cancer, Type 2 diabetes and neurodegenerative disorders, heightening interest and accelerating progress in dissecting out the control and functions of mTOR.|*Disease[MESH]|Amino Acids/metabolism[MESH]|Humans[MESH]|Organ Specificity[MESH]|Protein Kinases/*metabolism[MESH]|Signal Transduction[MESH]|TOR Serine-Threonine Kinases[MESH]|Transcription Factors/metabolism[MESH] |