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lüll Alzheimer abnormalities of the amygdala with Kluver-Bucy syndrome symptoms: an amygdaloid variant of Alzheimer disease Kile SJ; Ellis WG; Olichney JM; Farias S; DeCarli CArch Neurol 2009[Jan]; 66 (1): 125-9BACKGROUND: Neurofibrillary tangles and beta-amyloid plaques have been observed in the amygdala in Alzheimer disease. A disproportionate abundance of this abnormality in the amygdala may cause behavioral symptoms similar to Kluver-Bucy syndrome. OBJECTIVES: To describe an atypical behavioral presentation of Alzheimer disease and to review the literature on the subject. DESIGN: Case study. SETTING: Outpatient specialty clinic. PATIENT: A 70-year-old man with progressive behavioral symptoms of hyperorality, hypersexuality, hypermetamorphosis, visual agnosia, hyperphagia, and apathy who died at age 77 of asphyxiation on a foreign object. MAIN OUTCOME MEASURES: Clinical symptomatology, brain imaging, and neuropathology. RESULTS: The pathologic diagnosis was Alzheimer disease with abundant tangles and plaques in the lateral amygdala. CONCLUSIONS: This case represents a variant of Alzheimer disease with prominent amygdala abnormalities and a Kluver-Bucy phenotype that was misdiagnosed as frontotemporal dementia. Clinical and imaging findings that may aid in accurate diagnosis are reviewed.|Aged[MESH]|Alzheimer Disease/*complications/*pathology/physiopathology[MESH]|Amygdala/diagnostic imaging/*pathology/physiopathology[MESH]|Autopsy[MESH]|Dementia/diagnosis[MESH]|Diagnosis, Differential[MESH]|Diagnostic Errors/prevention & control[MESH]|Disease Progression[MESH]|Fatal Outcome[MESH]|Humans[MESH]|Kluver-Bucy Syndrome/*etiology/*pathology/physiopathology[MESH]|Magnetic Resonance Imaging[MESH]|Male[MESH]|Neurofibrillary Tangles/pathology[MESH]|Neuropsychological Tests[MESH]|Plaque, Amyloid/pathology[MESH]|Positron-Emission Tomography[MESH]|Retrospective Studies[MESH] |