Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
l�ll
Targeted delivery of nucleic-acid-based therapeutics to the pulmonary circulation Kuruba R; Wilson A; Gao X; Li SAAPS J 2009[Mar]; 11 (1): 23-30Targeted delivery of functional nucleic acids (genes and oligonucleotides) to pulmonary endothelium may become a novel therapy for the treatment of various types of lung diseases. It may also provide a new research tool to study the functions and regulation of novel genes in pulmonary endothelium. Its success is largely dependent on the development of a vehicle that is capable of efficient pulmonary delivery with minimal toxicity. This review summarizes the recent progress that has been made in our laboratory along these research directions. Factors that affect pulmonary nucleic acids delivery are also discussed.|*Pulmonary Circulation[MESH]|Administration, Inhalation[MESH]|Animals[MESH]|Antigens, Surface/drug effects[MESH]|Cations/pharmacokinetics[MESH]|Dependovirus/genetics[MESH]|Drug Carriers/administration & dosage/pharmacokinetics[MESH]|Drug Delivery Systems/*methods[MESH]|Endothelial Cells/drug effects[MESH]|Genetic Therapy/methods[MESH]|Genetic Vectors/administration & dosage/pharmacokinetics[MESH]|Humans[MESH]|Injections, Intravenous[MESH]|Lipids/administration & dosage/pharmacokinetics[MESH]|Liposomes/administration & dosage/pharmacokinetics[MESH]|Lung/*blood supply/cytology[MESH]|Mice[MESH]|Nucleic Acids/administration & dosage/*pharmacokinetics/therapeutic use[MESH]|Oligonucleotides/administration & dosage/pharmacokinetics/therapeutic use[MESH]|Peptides/administration & dosage/pharmacokinetics[MESH]|Polymers/pharmacokinetics[MESH]|RNA, Small Interfering/administration & dosage/pharmacokinetics/therapeutic use[MESH] |