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lüll Physiologie der Blutgerinnung und Fibrinolyse: Biochemie Preissner KTHamostaseologie 2008[Dec]; 28 (5): 259-71The principles of initiator and amplifications reactions of blood coagulation and fibrinolysis will be presented and discussed in relation to various regulatory pathways of haemostasis. In particular, cell surface-dependent activation and inhibition reactions are characteristics of multicomponent enzyme complexes that also allow the endogenous control of the haemostasis system. The understanding of these relationships in complications of haemostasis has lead to different strategies for the therapeutic intervention with pro- and anticoagulant substances.|Anticoagulants/therapeutic use[MESH]|Blood Coagulation Factors/metabolism[MESH]|Blood Coagulation/*physiology[MESH]|Coagulants/therapeutic use[MESH]|Fibrinolysin/physiology[MESH]|Fibrinolysis/*physiology[MESH]|Hemostasis/physiology[MESH]|Heparin/therapeutic use[MESH]|Humans[MESH]|Multienzyme Complexes/metabolism[MESH]|Serpins/metabolism[MESH] |