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lüll T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity Stone JD; Chervin AS; Kranz DMImmunology 2009[Feb]; 126 (2): 165-76The interaction between the T-cell receptor (TCR) and its peptide-major histocompatibility complex (pepMHC) ligand plays a critical role in determining the activity and specificity of the T cell. The binding properties associated with these interactions have now been studied in many systems, providing a framework for a mechanistic understanding of the initial events that govern T-cell function. There have been various other reviews that have described the structural and biochemical features of TCR : pepMHC interactions. Here we provide an overview of four areas that directly impact our understanding of T-cell function, as viewed from the perspective of the TCR : pepMHC interaction: (1) relationships between T-cell activity and TCR : pepMHC binding parameters, (2) TCR affinity, avidity and clustering, (3) influence of coreceptors on pepMHC binding by TCRs and T-cell activity, and (4) impact of TCR binding affinity on antigenic peptide specificity.|Epitopes, T-Lymphocyte/immunology[MESH]|Humans[MESH]|Ligands[MESH]|Lymphocyte Activation/immunology[MESH]|Major Histocompatibility Complex/immunology[MESH]|Peptides/immunology[MESH]|Protein Binding/immunology[MESH]|Receptors, Antigen, T-Cell/*metabolism[MESH]|T-Lymphocyte Subsets/*immunology[MESH] |