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lüll BRCA1, hormone, and tissue-specific tumor suppression Hu YInt J Biol Sci 2009[]; 5 (1): 20-7Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.|BRCA1 Protein/*genetics[MESH]|Breast Neoplasms/*genetics[MESH]|Cell Proliferation[MESH]|Estrogens/biosynthesis/*metabolism[MESH]|Female[MESH]|Genetic Predisposition to Disease/*genetics[MESH]|Genomic Instability/*genetics[MESH]|Germ-Line Mutation/genetics[MESH]|Humans[MESH]|Progesterone/*metabolism[MESH]|Signal Transduction/*physiology[MESH] |