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Intranasal administration of acetylcholinesterase inhibitors Costantino HR; Leonard AK; Brandt G; Johnson PH; Quay SCBMC Neurosci 2008[Dec]; 9 Suppl 3 (Suppl 3): S6This short review outlines the rationale, challenges, and opportunities for intranasal acetylcholinesterases, in particular galantamine. An in vitro screening model facilitated the development of a therapeutically viable formulation. In vivo testing confirmed achievement of therapeutically relevant drug levels that matched or exceeded those for oral dosing, with a dramatic reduction in undesired emetic responses. Intranasal drug delivery is an effective option for the treatment of Alzheimer's disease and other central nervous system disorders.|Administration, Intranasal[MESH]|Alzheimer Disease/*drug therapy/metabolism[MESH]|Animals[MESH]|Blood-Brain Barrier/*metabolism[MESH]|Central Nervous System Diseases/*drug therapy/metabolism[MESH]|Cholinesterase Inhibitors/*administration & dosage/pharmacokinetics/therapeutic use[MESH]|Galantamine/administration & dosage/pharmacokinetics/therapeutic use[MESH]|Humans[MESH] |
