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Antiphospholipid syndrome Espinosa G; Cervera RArthritis Res Ther 2008[]; 10 (6): 230Antiphospholipid syndrome is diagnosed when arterial or venous thrombosis or recurrent miscarriages occur in a person in whom laboratory tests for antiphospholipid antibodies (anticardiolipin antibodies and/or lupus anticoagulant and/or anti-beta 2-glycoprotein I) are positive. Despite the strong association between antiphospho-lipid antibodies and thrombosis, their pathogenic role in the development of thrombosis has not been fully elucidated. Novel mechanisms involving both the complement pathway and micro-particles have been described. The knowledge of these new pathogenic approaches might identify novel therapeutic targets and therefore may improve the management of these patients.|Animals[MESH]|Antibodies, Antiphospholipid/immunology[MESH]|Antiphospholipid Syndrome/complications/*diagnosis/*immunology[MESH]|Complement Pathway, Classical/immunology[MESH]|Humans[MESH]|Thrombosis/complications/immunology[MESH] |
