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lüll Polybromo-1: the chromatin targeting subunit of the PBAF complex Thompson MBiochimie 2009[Mar]; 91 (3): 309-19The human Polybromo-1 protein (Pb1) was recently identified as a unique subunit of the PBAF (Polybromo, Brg1-Associated Factors) chromatin-remodeling complex required for kinetochore localization during mitosis and the transcription of estrogen-responsive genes. Pb1 coordinates key features common to all remodeling complexes, including chromatin localization, recruitment of protein subunits and alteration of chromatin architecture. A comprehensive analysis of individual domains composing Pb1 is used to propose new information regarding the function of Pb1 in the PBAF chromatin-remodeling complex. The newly identified regulatory role of this important protein is also examined to explain both native function and the emerging role of Pb1 as a tumor suppressor found to be mutated in breast cancer.|*Chromatin Assembly and Disassembly[MESH]|Amino Acid Sequence[MESH]|DNA-Binding Proteins[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Mutation[MESH]|Nuclear Proteins/chemistry/*genetics/metabolism[MESH]|Protein Binding[MESH]|Protein Isoforms/chemistry/genetics/metabolism[MESH]|Protein Structure, Tertiary/genetics[MESH]|Recombinant Proteins/chemistry/isolation & purification/metabolism[MESH]|Sequence Homology, Amino Acid[MESH]|Transcription Factors/chemistry/*genetics/metabolism[MESH] |