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lüll Hepatitis C in the elderly: epidemiology, natural history, and treatment Mindikoglu AL; Miller RRClin Gastroenterol Hepatol 2009[Feb]; 7 (2): 128-34; quiz 124Hepatitis C continues to be a major public health problem affecting approximately 3% of the global population. According to the World Health Organization, an estimated 170 million people have chronic hepatitis C. Ten percent to 20% of those who are chronically infected with hepatitis C will progress to cirrhosis and 5% will develop hepatocellular carcinoma. Although the safety and efficacy of hepatitis C therapies have been studied extensively in patients between the ages of 18 and 65, patients who are older than 65 still remain an understudied and difficult-to-treat population. This review discusses the epidemiology, natural history, and treatment of chronic hepatitis C in older adults.|Adult[MESH]|Aged[MESH]|Aged, 80 and over[MESH]|Hepatitis C, Chronic/*drug therapy/*epidemiology/pathology/physiopathology[MESH]|Humans[MESH]|Interferon alpha-2[MESH]|Interferon-alpha/*therapeutic use[MESH]|Interferons/*therapeutic use[MESH]|Middle Aged[MESH]|Polyethylene Glycols/*therapeutic use[MESH]|Recombinant Proteins[MESH] |