Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Advances in the use of biologic agents for the treatment of systemic vasculitis Chung SA; Seo PCurr Opin Rheumatol 2009[Jan]; 21 (1): 3-9PURPOSE OF REVIEW: Due to the well known toxicities of cyclophosphamide, substantial interest exists in finding other therapies to treat primary systemic vasculitis. Biologic agents have been proposed as an alternative to cyclophosphamide for these disorders because of their recent success in treating other rheumatic diseases. This article reviews the current state-of-the-art therapy with regards to the use of biologic agents as treatments for systemic vasculitis. RECENT FINDINGS: The greatest amount of experience with these agents for the treatment of systemic vasculitis is with antitumor necrosis factor agents, pooled intravenous immunoglobulin, and anti-B-cell therapies such as rituximab. Intravenous immunoglobulin is already a standard therapy for Kawasaki's disease, but should also be considered for the treatment of vasculitis associated with antineutrophil cytoplasmic antibodies when standard therapies are either ineffective or contraindicated. Early experience with tumor necrosis factor inhibitors indicates that they may be effective for the treatment of Takayasu's arteritis, but their role in the treatment of other forms of vasculitis remains controversial. Early experience with rituximab for the treatment of several forms of vasculitis has been quite promising, but must be confirmed by ongoing randomized clinical trials. SUMMARY: Biologic agents represent the next evolution in treatment for the primary systemic vasculitides. Greater understanding of these diseases has allowed us to move further away from nonspecific, highly toxic therapies toward a more directed approach. As our experience with these agents increases, they will likely form the keystone of treatment in the near future.|Antibodies, Monoclonal, Murine-Derived[MESH]|Antibodies, Monoclonal/pharmacology/therapeutic use[MESH]|Biological Products/pharmacology/*therapeutic use[MESH]|Clinical Trials as Topic/trends[MESH]|Humans[MESH]|Immunoglobulins, Intravenous/pharmacology/therapeutic use[MESH]|Immunologic Factors/pharmacology/therapeutic use[MESH]|Immunosuppression Therapy/methods/trends[MESH]|Immunosuppressive Agents/pharmacology/*therapeutic use[MESH]|Rituximab[MESH]|Tumor Necrosis Factor-alpha/antagonists & inhibitors/physiology[MESH]|Vasculitis/*drug therapy/immunology/physiopathology[MESH] |
