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lüll Membrane rafts and caveolae in cardiovascular signaling Insel PA; Patel HHCurr Opin Nephrol Hypertens 2009[Jan]; 18 (1): 50-6PURPOSE OF REVIEW: Substantial evidence documents the key role of lipid (membrane) rafts and caveolae as microdomains that concentrate a wide variety of receptors and postreceptor components regulated by hormones, neurotransmitters and growth factors. RECENT FINDINGS: Recent data document that these microdomains are important in regulating vascular endothelial and smooth muscle cells and renal epithelial cells, and particularly in signal transduction across the plasma membrane. SUMMARY: Raft/caveolae domains are cellular regions, including in cardiovascular and renal epithelial cells, which organize a large number of signal transduction components, thereby providing spatially and temporally efficient regulation of cell function.|*Cardiovascular Physiological Phenomena[MESH]|Animals[MESH]|Caveolae/*physiology[MESH]|Endothelium, Vascular/metabolism/physiology[MESH]|Epithelial Cells/physiology[MESH]|Humans[MESH]|Kidney/metabolism[MESH]|Membrane Microdomains/*physiology[MESH]|Signal Transduction/*physiology[MESH] |