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Voltage-sensing phosphatase: actions and potentials Okamura Y; Murata Y; Iwasaki HJ Physiol 2009[Feb]; 587 (3): 513-20Voltage sensors have been well studied in voltage-gated ion channels for neuronal excitation and muscle contraction. The recent discovery of a voltage-sensing phosphatase, VSP, has changed the idea that voltage sensors are unique to ion flux through membranes. Recent findings on mechanisms and potential applications of VSP are reviewed.|Animals[MESH]|Enzyme Activation[MESH]|Humans[MESH]|Ion Channel Gating/physiology[MESH]|Ion Channels/chemistry/metabolism[MESH]|Membrane Potentials[MESH]|Neurons/enzymology/*physiology[MESH]|PTEN Phosphohydrolase/chemistry/metabolism[MESH]|Phosphatidylinositol Phosphates/metabolism[MESH]|Phosphoric Monoester Hydrolases/*physiology[MESH]|Phosphotransferases (Alcohol Group Acceptor)/metabolism[MESH]|Protein Structure, Tertiary/physiology[MESH] |
