Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Challenge and promise: roles for Livin in progression and therapy of cancer Wang L; Zhang Q; Liu B; Han M; Shan BMol Cancer Ther 2008[Dec]; 7 (12): 3661-9Livin is a member of the inhibitors of apoptosis protein gene family, which is highly expressed in a variety of human neoplasms. Several studies have shown that down-regulation of Livin expression increases the apoptotic rate, reduces tumor growth potential, and sensitizes tumor cells to chemotherapeutic drugs. Furthermore, emerging data reveal that Livin fragments cleavaged by caspases restored paradoxical proapoptotic activity during the apoptotic process, suggesting that Livin cleavage will become a highly potent proapoptotic agent in the future. In this article, we review the current understanding of the versatile roles of Livin in the apoptotic cascade and exploit the promising approach to interfere with Livin as a novel strategy for cancer therapy.|*Gene Expression Regulation, Neoplastic[MESH]|Adaptor Proteins, Signal Transducing/metabolism/*physiology[MESH]|Animals[MESH]|Antineoplastic Agents/pharmacology[MESH]|Apoptosis[MESH]|Caspases/metabolism[MESH]|Cell Line, Tumor[MESH]|Disease Progression[MESH]|Humans[MESH]|Inhibitor of Apoptosis Proteins/metabolism/*physiology[MESH]|Models, Biological[MESH]|Neoplasm Proteins/metabolism/*physiology[MESH]|Neoplasms/*pathology/*therapy[MESH]|Prognosis[MESH]|Protein Biosynthesis[MESH]|Protein Structure, Tertiary[MESH]|Transcription, Genetic[MESH] |