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lüll Presenilin: RIP and beyond Hass MR; Sato C; Kopan R; Zhao GSemin Cell Dev Biol 2009[Apr]; 20 (2): 201-10Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through gamma-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of beta-catenin function, protein trafficking, calcium regulation, and apoptosis.|Amyloid Precursor Protein Secretases/*metabolism[MESH]|Humans[MESH]|Membrane Proteins/*metabolism[MESH]|Models, Biological[MESH]|Presenilins/*metabolism[MESH]|Protein Transport[MESH]|Signal Transduction[MESH] |