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  lüll Organophosphate and carbamate poisoning: review of the current literature and  summary of clinical and laboratory experience in southern Israel Leibson T; Lifshitz MIsr Med Assoc J  2008[Nov]; 10 (11): 767-70Organophosphate and carbamate are mainly used to kill insects, thereby protecting  livestock, crops, homes and communities. Yet, these compounds also convey great  danger. OP and CRB poisoning is an important clinical problem, often  life-threatening, especially in the pediatric population in rural areas where  reaching a physician or hospital on time is difficult. We present a summary of  accumulated toxicological knowledge as well as clinical and laboratory experience  from a medical center serving a relatively vast rural area and pediatric  population. We stress the importance of knowing how to recognize the classic  signs of OP and CRB poisoning and when it is appropriate to investigate for such  poisoning even in the absence of those signs. Like any medical emergency, OP and  CRB poisoning requires prompt resuscitation and use of antidotes. Atropine,  oxygen and fluids are the mainstay of therapy. Oximes, which were found useful in  some cases of OP poisoning and useless in some cases of CRB poisoning, are  absolutely safe as empiric treatment, which is often needed since the major  differential diagnosis of OP poisoning is CRB poisoning, which is clinically  indistinguishable. We hope that continuing research will offer further insights  into the management of such events, and we are confident that improved medical  management of OP and CRB poisoning will result in a reduction of morbidity and  other complications associated with intensive care procedures and  hospitalization.|*Organophosphate Poisoning[MESH]|Atropine/therapeutic use[MESH]|Carbamates/*poisoning[MESH]|Humans[MESH]|Israel[MESH]|Muscarinic Antagonists/therapeutic use[MESH]|Poisoning/diagnosis/therapy[MESH]|Treatment Outcome[MESH] |