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lüll Deferoxamine mesylate: a new hope for intracerebral hemorrhage: from bench to clinical trials Selim MStroke 2009[Mar]; 40 (3 Suppl): S90-1Iron resulting from hemoglobin degradation is linked to delayed neuronal injury after intracerebral hemorrhage. Extensive preclinical investigations indicate that the iron chelator, deferoxamine mesylate, is effective in limiting hemoglobin- and iron-mediated neurotoxicity. However, clinical studies evaluating the use of deferoxamine in intracerebral hemorrhage are shortcoming. This article reviews the potential role of deferoxamine as a promising neuroprotective agent to target the secondary effects of intracerebral hemorrhage to limit brain injury and improve outcome, and ongoing efforts to translate the preclinical findings into clinical investigations.|Animals[MESH]|Cerebral Hemorrhage/complications/*drug therapy[MESH]|Chemotherapy, Adjuvant[MESH]|Deferoxamine/*therapeutic use[MESH]|Disease Models, Animal[MESH]|Hemoglobins/adverse effects[MESH]|Humans[MESH]|Nerve Degeneration/etiology/prevention & control[MESH]|Siderophores/*therapeutic use[MESH] |