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lüll Modified citrus pectin anti-metastatic properties: one bullet, multiple targets Glinsky VV; Raz ACarbohydr Res 2009[Sep]; 344 (14): 1788-91In this minireview, we examine the ability of modified citrus pectin (MCP), a complex water soluble indigestible polysaccharide obtained from the peel and pulp of citrus fruits and modified by means of high pH and temperature treatment, to affect numerous rate-limiting steps in cancer metastasis. The anti-adhesive properties of MCP as well as its potential for increasing apoptotic responses of tumor cells to chemotherapy by inhibiting galectin-3 anti-apoptotic function are discussed in the light of a potential use of this carbohydrate-based substance in the treatment of multiple human malignancies.|Animals[MESH]|Anoikis/drug effects[MESH]|Antineoplastic Agents, Phytogenic/*therapeutic use[MESH]|Apoptosis/drug effects[MESH]|Citrus/chemistry[MESH]|Galectin 3/antagonists & inhibitors[MESH]|Humans[MESH]|Neoplasm Invasiveness/physiopathology[MESH]|Neoplasm Metastasis/*drug therapy[MESH]|Neovascularization, Pathologic/drug therapy[MESH]|Pectins/chemistry/*therapeutic use[MESH]|Plant Extracts[MESH] |