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lüll Acanthosis nigricans: a practical approach to evaluation and management Higgins SP; Freemark M; Prose NSDermatol Online J 2008[Sep]; 14 (9): 2Acanthosis nigricans is a dermatosis characterized by thickened, hyperpigmented plaques, typically of the intertriginous surfaces and neck. Common in some populations, its prevalence depends on race. Clinicians should recognize acanthosis nigricans; it heralds disorders ranging from endocrinologic disturbances to malignancy. In this review, we discuss the pathogenesis of acanthosis nigricans and its clinical implications and management.|*Acanthosis Nigricans/diagnosis/drug therapy/epidemiology/etiology/pathology/radiotherapy[MESH]|Adolescent[MESH]|Calcitriol/analogs & derivatives/pharmacology[MESH]|Child[MESH]|Disease Susceptibility[MESH]|Ethnicity/genetics[MESH]|Female[MESH]|Fish Oils/therapeutic use[MESH]|Humans[MESH]|Hypoglycemic Agents/therapeutic use[MESH]|Insulin Resistance[MESH]|Insulin-Like Growth Factor I/physiology[MESH]|Low-Level Light Therapy[MESH]|Male[MESH]|Neoplasms/complications[MESH]|Prevalence[MESH]|Receptor Protein-Tyrosine Kinases/physiology[MESH]|Retinoids/therapeutic use[MESH] |