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Lipid rafts and caveolae and their role in compartmentation of redox signaling Patel HH; Insel PAAntioxid Redox Signal 2009[Jun]; 11 (6): 1357-72Membrane (lipid) rafts and caveolae, a subset of rafts, are cellular domains that concentrate plasma membrane proteins and lipids involved in the regulation of cell function. In addition to providing signaling platforms for G-protein-coupled receptors and certain tyrosine kinase receptors, rafts/caveolae can influence redox signaling. This review discusses molecular characteristics of and methods to study rafts/caveolae, determinants that contribute to the localization of molecules in these entities, an overview of signaling molecules that show such localization, and the contribution of rafts/caveolae to redox signaling. Of particular note is the evidence that endothelial nitric oxide synthase (eNOS), NADPH oxygenase, and heme oxygenase, along with other less well-studied redox systems, localize in rafts and caveolae. The precise basis for this localization and the contribution of raft/caveolae-localized redox components to physiology and disease are important issues for future studies.|Animals[MESH]|Caveolae/*metabolism/ultrastructure[MESH]|Cell Membrane/*metabolism/ultrastructure[MESH]|Humans[MESH]|Membrane Lipids/metabolism[MESH]|Membrane Microdomains/*metabolism/ultrastructure[MESH]|Models, Biological[MESH]|Oxidation-Reduction[MESH]|Signal Transduction/*physiology[MESH] |
