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lüll Cefepime: a reappraisal in an era of increasing antimicrobial resistance Endimiani A; Perez F; Bonomo RAExpert Rev Anti Infect Ther 2008[Dec]; 6 (6): 805-24Cefepime is a 'fourth-generation' cephalosporin with an in vitro extended-spectrum of activity against Gram-negative and Gram-positive pathogens. Cefepime is approved for the treatment of moderate-to-severe infections, such as pneumonia, uncomplicated and complicated urinary tract infections, skin and soft-tissue infections, intra-abdominal infections and febrile neutropenia. In this article, we provide a critical review of pharmacodynamics, clinical management, pharmacokinetics, metabolism, pharmacodynamic target analyses, clinical efficacy, safety and tolerability of cefepime after more than a decade of clinical use.|Aged[MESH]|Aged, 80 and over[MESH]|Anti-Bacterial Agents/chemistry/pharmacology/*therapeutic use[MESH]|Bacterial Infections/*drug therapy[MESH]|Cefepime[MESH]|Cephalosporins/chemistry/pharmacology/*therapeutic use[MESH]|Child[MESH]|Drug Resistance, Bacterial[MESH]|Gram-Negative Bacteria/drug effects/pathogenicity[MESH]|Gram-Positive Bacteria/drug effects/pathogenicity[MESH]|Humans[MESH]|Retrospective Studies[MESH] |