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lüll Ketone bodies, glycolysis, and KATP channels in the mechanism of the ketogenic diet Yellen GEpilepsia 2008[Nov]; 49 Suppl 8 (Suppl 8): 80-2The ketogenic diet (KD) has shown remarkable efficacy in the treatment of drug-resistant childhood epilepsy. Our understanding of how the KD produces its anticonvulsant and antiepileptogenic effects remains incomplete, which is perhaps not surprising for a biological manipulation as sweeping as dietary change. Several hypotheses focus on ketone bodies, fuel molecules that circulate at millimolar concentrations in the blood of patients on a KD, as causative agents. Here I consider some recent evidence for one such hypothesis, involving a possible role for altered glycolysis and consequent activation of a class of potassium channels called K(ATP)channels.|*Diet, Ketogenic[MESH]|Animals[MESH]|Brain/metabolism[MESH]|Epilepsy/*diet therapy[MESH]|Glycolysis/*physiology[MESH]|Humans[MESH]|KATP Channels/*metabolism[MESH]|Ketone Bodies/*metabolism[MESH] |