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lüll Targeting the stroma by T cells to limit tumor growth Zhang BCancer Res 2008[Dec]; 68 (23): 9570-3Solid tumors may modulate their environment and keep stromal cells in an immunosuppressive and tumor-promoting state. Recent findings indicate that targeting not only cancer cells but also nonmalignant stromal cells by T cells is required for the eradication of established tumor. Interestingly, a single adoptive transfer of effector T cells that recognize tumor antigen-loaded stromal cells, but not the cancer cells themselves, causes long-term inhibition of tumor growth associated with T cell-mediated killing of stromal CD11b+/Gr1+ myeloid cells. Therefore, targeting tumor stroma by T cells points to an important alternative approach to the effective control of tumor growth, particularly in the absence of direct targeting of cancer cells.|Animals[MESH]|Antigen Presentation[MESH]|Antigens, Neoplasm/immunology[MESH]|Cell Growth Processes/immunology[MESH]|Humans[MESH]|Immunotherapy, Adoptive/*methods[MESH]|Neoplasms/*immunology/pathology/*therapy[MESH]|Stromal Cells/immunology/pathology[MESH]|T-Lymphocytes/*immunology[MESH] |