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  lüll Louse- and flea-borne rickettsioses: biological and genomic analyses Gillespie JJ; Ammerman NC; Beier-Sexton M; Sobral BS; Azad AFVet Res  2009[Mar]; 40 (2): 12In contrast to 15 or more validated and/or proposed tick-borne spotted fever  group species, only three named medically important rickettsial species are  associated with insects. These insect-borne rickettsiae are comprised of two  highly pathogenic species, Rickettsia prowazekii (the agent of epidemic typhus)  and R. typhi (the agent of murine typhus), as well as R. felis, a species with  unconfirmed pathogenicity. Rickettsial association with obligate hematophagous  insects such as the human body louse (R. prowazekii transmitted by Pediculus h.  humanus) and several flea species (R. typhi and R. felis, as well as R.  prowazekii in sylvatic form) provides rickettsiae the potential for further  multiplications, longer transmission cycles and rapid spread among susceptible  human populations. Both human body lice and fleas are intermittent feeders  capable of multiple blood meals per generation, facilitating the efficient  transmission of rickettsiae to several disparate hosts within urban/rural  ecosystems. While taking into consideration the existing knowledge of rickettsial  biology and genomic attributes, we have analyzed and summarized the interacting  features that are unique to both the rickettsiae and their vector fleas and lice.  Furthermore, factors that underlie rickettsial changing ecology, where native  mammalian populations are involved in the maintenance of rickettsial cycle and  transmission, are discussed.|Animals[MESH]|Insect Vectors/*microbiology[MESH]|Phthiraptera/*microbiology[MESH]|Rickettsia Infections/*microbiology/*transmission[MESH]|Rickettsia/genetics/*physiology[MESH]|Siphonaptera/*microbiology[MESH] |